UCHealth has begun its second large-scale, human trial aimed at developing a vaccine for COVID-19, the hospital system said on Thursday.
The trial, which will test drug-maker AstraZeneca鈥檚 main vaccine candidate, will last around two years and recruit residents from communities across Northern Colorado. It鈥檚 part of a national effort to study the efficacy of the vaccine on more than 30,000 adults. Early results could help the company gain emergency approval from federal regulators and, ultimately, clear the pathway to distribute a vaccine to the public.
Dr. Gary Luckason, medical director of UCHealth鈥檚 clinical research program in Northern Colorado, said researchers want to enroll between 1,500 to 2,000 local participants between now and Thanksgiving. The group is mainly looking for workers in professions that carry a greater risk of exposure to the coronavirus, including medical workers, grocery store clerks and first responders.
In the trial, two out of three participants will receive a vaccine. The other third will receive a placebo injection. The large population size, Luckason said, will help researchers determine if those who do receive the vaccine develop immunity.
鈥淲e don鈥檛 have a lot of medicines that treat (COVID-19),鈥� Luckason said. 鈥淪o the goal for us to get back to normal life is to protect you so you don鈥檛 get the disease and that鈥檚 the goal of a vaccine.鈥�
The AstraZeneca trial is one of many moving forward at breakneck speed. At least 11 candidates, including AstraZeneca鈥檚, have entered 鈥減hase 3鈥� clinical trials, according to a . Phase 3 denotes large-scale, human testing. It鈥檚 the final phase before regulators can grant emergency authorization to drug makers.
It鈥檚 still unclear when a vaccine will be widely available to the public. But Colorado has already started preparing for how it will be distributed.
UCHealth launched enrollment in Colorado for another COVID-19 vaccine trial, by drug-maker Moderna, The AstraZeneca trial in Northern Colorado was set to take place earlier this fall, but was delayed after an 鈥渦nexplained illness鈥� appeared in a participant of a similar trial taking place in the United Kingdom.
The Food and Drug Administration reviewed the incident and, , gave the company permission to proceed with more trials.
The trial in Northern Colorado will mainly take place at The Ranch 萝莉少女 Complex in Loveland. Participants must be pre-screened before enrolling.
